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      <title>Biomedical and Environmental Sciences</title>
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    <description><![CDATA[《Biomedical and Environmental Sciences》2024年第4期]]></description>
    <year><![CDATA[2024]]></year>
    <volume><![CDATA[37]]></volume>
    <issue><![CDATA[4]]></issue>
    	    <item>
	       	<title>Cover</title>
	      	<link>//article/id/90590141-6240-4b7c-a1da-88d5ad0bb611</link>
	     	<description><![CDATA[]]></description>
	      	<volume>37</volume>
	      	<issue>4</issue>
	      	<startPage></startPage>
	      	<endPage></endPage>
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    	    <item>
	       	<title>2024-4 Contents</title>
	      	<link>//article/id/350af4d7-d037-4b95-a51c-2b610b9bc9d0</link>
	     	<description><![CDATA[]]></description>
	      	<volume>37</volume>
	      	<issue>4</issue>
	      	<startPage>1</startPage>
	      	<endPage>2</endPage>
	      	<author>
				
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    	    <item>
	       	<title>Proteomics Study of Benzene Metabolite Hydroquinone Induced Hematotoxicity in K562 Cells</title>
	      	<link>//article/id/921e642a-c10e-4701-98bb-682d487a9eb7</link>
	     	<description><![CDATA[&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Objective&amp;lt;/b&amp;lt;  &amp;nbsp;Hydroquinone (HQ), one of the phenolic metabolites of benzene, is widely recognized as an important participant in benzene-induced hematotoxicity. However, there are few relevant proteomics in HQ-induced hematotoxicity and the mechanism hasn’t been fully understood yet.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Methods&amp;lt;/b&amp;lt;  &amp;nbsp;In this study, we treated K562 cells with 40 μmol/L HQ for 72 h, examined and validated protein expression changes by Label-free proteomic analysis and Parallel reaction monitoring (PRM), and performed bioinformatics analysis to identify interaction networks.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Results&amp;lt;/b&amp;lt;  &amp;nbsp;One hundred and eighty-seven upregulated differentially expressed proteins (DEPs) and 279 downregulated DEPs were identified in HQ-exposed K562 cells, which were involved in neutrophil-mediated immunity, blood microparticle, and other GO terms, as well as the lysosome, metabolic, cell cycle, and cellular senescence-related pathways. Focusing on the 23 DEGs and 5 DEPs in erythroid differentiation-related pathways, we constructed the network of protein interactions and determined 6 DEPs (STAT1, STAT3, CASP3, KIT, STAT5B, and VEGFA) as main hub proteins with the most interactions, among which STATs made a central impact and may be potential biomarkers of HQ-induced hematotoxicity.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Conclusion&amp;lt;/b&amp;lt;  &amp;nbsp;Our work reinforced the use of proteomics and bioinformatic approaches to advance knowledge on molecular mechanisms of HQ-induced hematotoxicity at the protein level and provide a valuable basis for further clarification.&amp;lt;/sec&amp;lt;]]></description>
	      	<volume>37</volume>
	      	<issue>4</issue>
	      	<startPage>341</startPage>
	      	<endPage>353</endPage>
	      	<author>
				JIN Yi Shan, YI Zong Chun, ZHANG Yu Jing, RONG Long, YU Chun Hong
	      	</author>
	    </item>
    	    <item>
	       	<title>Downregulation of Serum PTEN Expression in Mercury-Exposed Population and PI3K/AKT Pathway-Induced Inflammation</title>
	      	<link>//article/id/4c94b408-b58c-41af-b7b3-03ee7f144a6a</link>
	     	<description><![CDATA[&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Objective&amp;lt;/b&amp;lt;  &amp;nbsp;This study investigated the impact of occupational mercury (Hg) exposure on human gene transcription and expression, and its potential biological mechanisms.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Methods&amp;lt;/b&amp;lt;  &amp;nbsp;Differentially expressed genes related to Hg exposure were identified and validated using gene expression microarray analysis and extended validation. Hg-exposed cell models and &amp;lt;i&amp;lt;PTEN&amp;lt;/i&amp;lt; low-expression models were established&amp;lt;i&amp;lt; in vitro&amp;lt;/i&amp;lt; using 293T cells. &amp;lt;i&amp;lt;PTEN&amp;lt;/i&amp;lt; gene expression was assessed using qRT-PCR, and Western blotting was used to measure PTEN, AKT, and PI3K protein levels. IL-6 expression was determined by ELISA.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Results&amp;lt;/b&amp;lt;  &amp;nbsp;Combined findings from gene expression microarray analysis, bioinformatics, and population expansion validation indicated significant downregulation of the &amp;lt;i&amp;lt;PTEN&amp;lt;/i&amp;lt; gene in the high-concentration Hg exposure group. In the Hg-exposed cell model (25 and 10 μmol/L), a significant decrease in PTEN expression was observed, accompanied by a significant increase in PI3K, AKT, and IL-6 expression. Similarly, a low-expression cell model demonstrated that &amp;lt;i&amp;lt;PTEN&amp;lt;/i&amp;lt; gene knockdown led to a significant decrease in PTEN protein expression and a substantial increase in PI3K, AKT, and IL-6 levels.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Conclusion&amp;lt;/b&amp;lt;  &amp;nbsp;This is the first study to report that Hg exposure downregulates the &amp;lt;i&amp;lt;PTEN&amp;lt;/i&amp;lt; gene, activates the PI3K/AKT regulatory pathway, and increases the expression of inflammatory factors, ultimately resulting in kidney inflammation.&amp;lt;/sec&amp;lt;]]></description>
	      	<volume>37</volume>
	      	<issue>4</issue>
	      	<startPage>354</startPage>
	      	<endPage>366</endPage>
	      	<author>
				MEI Peng, DING En Min, YIN Hao Yang, DING Xue Xue, WANG Huan, WANG Jian Feng, HAN Lei, ZHANG Heng Dong, ZHU Bao Li
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	       	<title>Salidroside Ameliorates Lung Injury Induced by PM&amp;lt;sub&amp;lt;2.5 &amp;lt;/sub&amp;lt;by Regulating SIRT1-PGC-1α in Mice</title>
	      	<link>//article/id/a62d1804-7c49-4710-a6b2-ccf9d791a9d9</link>
	     	<description><![CDATA[&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Objective&amp;lt;/b&amp;lt;  &amp;nbsp;This study aimed to clarify the intervention effect of salidroside (SAL) on lung injury caused by PM&amp;lt;sub&amp;lt;2.5&amp;lt;/sub&amp;lt; in mice and illuminate the function of SIRT1-PGC-1ɑ axis.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Methods&amp;lt;/b&amp;lt;  &amp;nbsp;Specific pathogen-free (SPF) grade male C57BL/6 mice were randomly assigned to the following groups: control group, SAL group, PM&amp;lt;sub&amp;lt;2.5&amp;lt;/sub&amp;lt; group, SAL+PM&amp;lt;sub&amp;lt;2.5&amp;lt;/sub&amp;lt; group. On the first day, SAL was given by gavage, and on the second day, PM&amp;lt;sub&amp;lt;2.5&amp;lt;/sub&amp;lt; suspension was given by intratracheal instillation. The whole experiment consist of a total of 10 cycles, lasting 20 days. At the end of treatment, blood samples and lung tissues were collected and analyzed. Observation of pathological changes in lung tissue using inverted microscopy and transmission electron microscopy. The expression of inflammatory, antioxidants, apoptosis, and SIRT1-PGC-1ɑ proteins were detected by Western blotting.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Results&amp;lt;/b&amp;lt;  &amp;nbsp;Exposure to PM&amp;lt;sub&amp;lt;2.5&amp;lt;/sub&amp;lt; leads to obvious morphological and pathologica changes in the lung of mice. PM&amp;lt;sub&amp;lt;2.5&amp;lt;/sub&amp;lt; caused a decline in levels of antioxidant-related enzymes and protein expressions of HO-1, Nrf2, SOD2, SIRT1 and PGC-1ɑ, and an increase in the protein expressions of IL-6, IL-1β, Bax, caspase-9 and cleaved caspase-3. However, SAL reversed the aforementioned changes caused by PM&amp;lt;sub&amp;lt;2.5&amp;lt;/sub&amp;lt; by activating the SIRT1-PGC-1α pathway.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Conclusion&amp;lt;/b&amp;lt;  &amp;nbsp;SAL can activate SIRT1-PGC-1ɑ to ameliorate PM&amp;lt;sub&amp;lt;2.5&amp;lt;/sub&amp;lt;-induced lung injury.&amp;lt;/sec&amp;lt;]]></description>
	      	<volume>37</volume>
	      	<issue>4</issue>
	      	<startPage>367</startPage>
	      	<endPage>376</endPage>
	      	<author>
				LI Xiao Hong, LIU Yu Mei, SHAN Hui, TAN Jin Feng, ZHOU Jian, SONG Yuan Jin, LI Si Qi, LIU Chen, XU Dong Qun, YU Li, LI Wan Wei
	      	</author>
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	       	<title>Barley Protein LFBEP-C1 from &amp;lt;i&amp;lt;Lactiplantibacillus plantarum dy-1&amp;lt;/i&amp;lt; Fermented Barley Extracts by Inhibiting Lipid Accumulation in a &amp;lt;i&amp;lt;Caenorhabditis elegans&amp;lt;/i&amp;lt; Model</title>
	      	<link>//article/id/6da993ef-7363-4a02-8957-98161eb37909</link>
	     	<description><![CDATA[&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Objective&amp;lt;/b&amp;lt;  &amp;nbsp;This study aimed to investigate the lipid-lowering activity of LFBEP-C1 in high glucose-fed &amp;lt;i&amp;lt;Caenorhabditis elegans (C. elegans)&amp;lt;/i&amp;lt;. &amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Methods&amp;lt;/b&amp;lt;  &amp;nbsp;In this study, the fermented barley protein LFBEP-C1 was prepared and tested for its potential anti-obesity effects on &amp;lt;i&amp;lt;C. elegans&amp;lt;/i&amp;lt;. The worms were fed &amp;lt;i&amp;lt;Escherichia coli&amp;lt;/i&amp;lt; OP50 (&amp;lt;i&amp;lt;E. coli&amp;lt;/i&amp;lt; OP50), glucose, and different concentrations of LFBEP-C1. Body size, lifespan, movement, triglyceride content, and gene expression were analyzed. The results were analyzed using ANOVA and Tukey&apos;s multiple comparison test. &amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Results&amp;lt;/b&amp;lt;  &amp;nbsp;Compared with the model group, the head-swing frequency of &amp;lt;i&amp;lt;C. elegans&amp;lt;/i&amp;lt; in the group of LFBEP-C1 at 20 μg/mL increased by 33.88%, and the body-bending frequency increased by 27.09%. This indicated that LFBEP-C1 improved the locomotive ability of &amp;lt;i&amp;lt;C. elegans.&amp;lt;/i&amp;lt; The average lifespan of &amp;lt;i&amp;lt;C. elegans&amp;lt;/i&amp;lt; reached 13.55 days, and the body length and width of the &amp;lt;i&amp;lt;C. elegans&amp;lt;/i&amp;lt; decreased after LFBEP-C1 intake. Additionally, LFBEP-C1 reduced the content of lipid accumulation and triglyceride levels. The expression levels of &amp;lt;i&amp;lt;sbp-1&amp;lt;/i&amp;lt;, &amp;lt;i&amp;lt;daf-2&amp;lt;/i&amp;lt;, and &amp;lt;i&amp;lt;mdt-15&amp;lt;/i&amp;lt; significantly decreased, while those of &amp;lt;i&amp;lt;daf-16&amp;lt;/i&amp;lt;, &amp;lt;i&amp;lt;tph-1&amp;lt;/i&amp;lt;, &amp;lt;i&amp;lt;mod-1&amp;lt;/i&amp;lt;, and &amp;lt;i&amp;lt;ser-4&amp;lt;/i&amp;lt; significantly increased after LFBEP-C1 intake. Changes in these genes explain the signaling pathways that regulate lipid metabolism. &amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Conclusion&amp;lt;/b&amp;lt;  &amp;nbsp;LFBEP-C1 significantly reduced lipid deposition in &amp;lt;i&amp;lt;C. elegans&amp;lt;/i&amp;lt; fed a high-glucose diet and alleviated the adverse effects of a high-glucose diet on the development, lifespan, and exercise behavior of &amp;lt;i&amp;lt;C. elegans&amp;lt;/i&amp;lt;. In addition, LFBEP-C1 regulated lipid metabolism mainly by mediating the expression of genes in the sterol regulatory element-binding protein, insulin, and 5-hydroxytryptamine signaling pathways.&amp;lt;/sec&amp;lt;]]></description>
	      	<volume>37</volume>
	      	<issue>4</issue>
	      	<startPage>377</startPage>
	      	<endPage>386</endPage>
	      	<author>
				ZHANG Jia Yan, LIU Meng Ting, LIU Yu Hao, DENG Huan, BAI Juan, XIE Jian Hua, XIAO Xiang
	      	</author>
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    	    <item>
	       	<title>Establishment of a Multiplex Detection Method for Common Bacteria in Blood Based on Human Mannan-Binding Lectin Protein-Conjugated Magnetic Bead Enrichment Combined with Recombinase-Aided PCR Technology</title>
	      	<link>//article/id/bc3bcabf-2a9f-423b-9a7d-7988e100a217</link>
	     	<description><![CDATA[&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Objective&amp;lt;/b&amp;lt;  &amp;nbsp;Recombinase-aided polymerase chain reaction (RAP) is a sensitive, single-tube, two-stage nucleic acid amplification method. This study aimed to develop an assay that can be used for the early diagnosis of three types of bacteremia caused by &amp;lt;i&amp;lt;Staphylococcus aureus&amp;lt;/i&amp;lt; (SA), &amp;lt;i&amp;lt;Pseudomonas aeruginosa&amp;lt;/i&amp;lt; (PA), and &amp;lt;i&amp;lt;Acinetobacter baumannii&amp;lt;/i&amp;lt; (AB) in the bloodstream based on recombinant human mannan-binding lectin protein (M1 protein)-conjugated magnetic bead (M1 bead) enrichment of pathogens combined with RAP.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Methods&amp;lt;/b&amp;lt;  &amp;nbsp;Recombinant plasmids were used to evaluate the assay sensitivity. Common blood influenza bacteria were used for the specific detection. Simulated and clinical plasma samples were enriched with M1 beads and then subjected to multiple recombinase-aided PCR (M-RAP) and quantitative PCR (qPCR) assays. Kappa analysis was used to evaluate the consistency between the two assays.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Results&amp;lt;/b&amp;lt;  &amp;nbsp; The M-RAP method had sensitivity rates of 1, 10, and 1 copies/μL for the detection of SA, PA, and AB plasmids, respectively, without cross-reaction to other bacterial species. The M-RAP assay obtained results for &amp;lt; 10 CFU/mL pathogens in the blood within 4 h, with higher sensitivity than qPCR. M-RAP and qPCR for SA, PA, and AB yielded Kappa values of 0.839, 0.815, and 0.856, respectively (&amp;lt;i&amp;lt;P&amp;lt;/i&amp;lt; &amp;lt; 0.05).&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Conclusion&amp;lt;/b&amp;lt;  &amp;nbsp;An M-RAP assay for SA, PA, and AB in blood samples utilizing M1 bead enrichment has been developed and can be potentially used for the early detection of bacteremia.&amp;lt;/sec&amp;lt;]]></description>
	      	<volume>37</volume>
	      	<issue>4</issue>
	      	<startPage>387</startPage>
	      	<endPage>398</endPage>
	      	<author>
				ZHAO Zi Jin, CHEN Xiao Ping, HUA Shao Wei, LI Feng Yu, ZHAO Meng, XING Chen Hao, WANG Jie, TIAN Feng Yu, ZHANG Rui Qing, LYU Xiao Na, HAN Zhi Qiang, WANG Yu Xin, LI Hong Yi, SHEN Xin Xin, MA Xue Jun, TIE Yan Qing
	      	</author>
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	       	<title>Characteristics of the HIV/AIDS Epidemic among People Aged ≥ 50 Years in China during 2018–2021</title>
	      	<link>//article/id/73f65479-1f5f-4993-a287-41b928dc129e</link>
	     	<description><![CDATA[&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Objective&amp;lt;/b&amp;lt;  &amp;nbsp;This study aimed to determine the current epidemiological status of PLWHA aged ≥ 50 years in China from 2018 to 2021. It also aimed to recommend targeted interventions for the prevention and treatment of HIV/AIDS in elderly patients.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Methods&amp;lt;/b&amp;lt;  &amp;nbsp;Data on newly reported cases of PLWHA, aged ≥ 50 years in China from 2018 to 2021, were collected using the CRIMS. Trend tests and spatial analyses were also conducted.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Results&amp;lt;/b&amp;lt;  &amp;nbsp;Between 2018 and 2021, 237,724 HIV/AIDS cases were reported among patients aged ≥ 50 years in China. The main transmission route was heterosexual transmission (91.24%). Commercial heterosexual transmission (CHC) was the primary mode of transmission among males, while non-marital non-CHC ([NMNCHC]; 60.59%) was the prevalent route in women. The proportion of patients with CHC decreased over time (&amp;lt;i&amp;lt;Z&amp;lt;/i&amp;lt; = 67.716, &amp;lt;i&amp;lt;P&amp;lt;/i&amp;lt; &amp;lt; 0.01), while that of patients with NMNCHC increased (&amp;lt;i&amp;lt;Z&amp;lt;/i&amp;lt; = 153.05, &amp;lt;i&amp;lt;P&amp;lt;/i&amp;lt; &amp;lt; 0.01). The sex ratio varied among the different modes of infection, and it peaked at 17.65 for CHC. The spatial analysis indicated spatial clustering, and the high-high clustering areas were mainly distributed in the southwestern and central-southern provinces.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Conclusion&amp;lt;/b&amp;lt;  &amp;nbsp;In China, PLWHA, aged ≥ 50 years, were predominantly infected through heterosexual transmission. The primary modes of infection were CHC and NMNCHC. There were variations in the sex ratio among different age groups, infected through various sexual behaviors. HIV/AIDS cases exhibited spatial clustering. Based on these results, the expansion of HIV testing, treatment, and integrated behavioral interventions in high-risk populations is recommended to enhance disease detection in key regions.&amp;lt;/sec&amp;lt;]]></description>
	      	<volume>37</volume>
	      	<issue>4</issue>
	      	<startPage>399</startPage>
	      	<endPage>405</endPage>
	      	<author>
				HOU Yu Shan, JIN Yi Chen, CAI Chang, TANG Hou Lin, QIN Qian Qian, LYU Fan
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    	    <item>
	       	<title>Numerical Simulation on Radon Retardation Behavior of Covering Floats in Radon-Containing Water</title>
	      	<link>//article/id/3616f920-9c7c-472c-80b9-e3837208eaf8</link>
	     	<description><![CDATA[&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Objective&amp;lt;/b&amp;lt;  &amp;nbsp;This study aimed to efficiently reduce the release of radon from water bodies to protect the environment.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Methods&amp;lt;/b&amp;lt;  &amp;nbsp;Based on the sizes of the experimental setup and modular float, computational fluid dynamics (CFD) was used to assess the impact of the area coverage rate, immersion depth, diffusion coefficient, and radon transfer velocity at the gas–liquid interface on radon migration and exhalation of radon-containing water. Based on the numerical simulation results, an estimation model for the radon retardation rate was constructed. The effectiveness of the CFD simulation was evaluated by comparing the experimental and simulated variation values of the radon retardation rate with the coverage area rates.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Results&amp;lt;/b&amp;lt;  &amp;nbsp;The effect of radon transfer velocity on radon retardation in water bodies was minor and insignificant according to the appropriate value; therefore, an estimation model of the radon retardation rate of the coverage of a radon-containing water body was constructed using the synergistic impacts of three factors: area coverage rate, immersion depth, and diffusion coefficient. The deviation between the experimental and simulated results was &amp;lt; 4.3%.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Conclusion&amp;lt;/b&amp;lt;  &amp;nbsp;Based on the numerical simulation conditions, an estimation model of the radon retardation rate of covering floats in water bodies under the synergistic effect of multiple factors was obtained, which provides a reference for designing covering floats for radon retardation in radon-containing water.&amp;lt;/sec&amp;lt;]]></description>
	      	<volume>37</volume>
	      	<issue>4</issue>
	      	<startPage>406</startPage>
	      	<endPage>417</endPage>
	      	<author>
				LIU Shu Yuan, ZHANG Li, YE Yong Jun, DING Ku Ke
	      	</author>
	    </item>
    	    <item>
	       	<title>Prevalence, Characteristics and Treatment of Knee Osteoarthritis in Urban Residents of Beijing, China: A Community-Based Cross-Sectional Study</title>
	      	<link>//article/id/6807713e-f9cd-45bc-a516-5b2e8ebd5f3f</link>
	     	<description><![CDATA[]]></description>
	      	<volume>37</volume>
	      	<issue>4</issue>
	      	<startPage>418</startPage>
	      	<endPage>422</endPage>
	      	<author>
				ZHOU Jun, YAN Yan, DONG Ya Wei, LIU Xiao Yu, WANG Ping, LIN Jia Ming, DONG Peng Xuan, QUAN Rui, WANG Rong Tian, MI Bao Hong, CHEN Wei Heng
	      	</author>
	    </item>
    	    <item>
	       	<title>WNT5A Regulated by miR154-5p is Associated with Angiopoiesis and Invasion of Placental Site Trophoblastic Tumor (PSTT)</title>
	      	<link>//article/id/9dc0dd88-66a1-433a-b4d9-c972cd43e608</link>
	     	<description><![CDATA[]]></description>
	      	<volume>37</volume>
	      	<issue>4</issue>
	      	<startPage>423</startPage>
	      	<endPage>427</endPage>
	      	<author>
				ZHANG Sai, CHEN Zhi Xian, ZHANG Mo, DU Yan, ZHOU Jia Yi, WU Jing, YU Yin Hua, CAO Qi, ZHAO Hong Bo
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	    </item>
    	    <item>
	       	<title>Lecanemab Unveiled: Exploring Alzheimer’s Treatment Advancements, Assessing Strengths, Limitations, and Its Therapeutic Landscape Position</title>
	      	<link>//article/id/be5f537f-0fda-4394-84f0-843d04b01a52</link>
	     	<description><![CDATA[]]></description>
	      	<volume>37</volume>
	      	<issue>4</issue>
	      	<startPage>428</startPage>
	      	<endPage>431</endPage>
	      	<author>
				VICTOR Abiola Adepoju, OKECHUKWU Innocent Onyezue, SAFAYET Jamil, OLALEKAN John Okesanya, DON Eliseo Lucero-Prisno III
	      	</author>
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    	    <item>
	       	<title>The First Reported Case of Co-Infection with &amp;lt;i&amp;lt;Neisseria&amp;lt;/i&amp;lt; &amp;lt;i&amp;lt;Meningitidis &amp;lt;/i&amp;lt;and &amp;lt;i&amp;lt;Bordetella Pertussis&amp;lt;/i&amp;lt; in the Cerebrospinal Fluid Specimen of a Normal Four-Year-Old Child</title>
	      	<link>//article/id/43b110ee-1dc0-4afc-88c9-738427b45ea3</link>
	     	<description><![CDATA[]]></description>
	      	<volume>37</volume>
	      	<issue>4</issue>
	      	<startPage>432</startPage>
	      	<endPage>435</endPage>
	      	<author>
				XIA Xian, LI Guo Ming, TANG Yi, WANG Si Quan, HE Fei, JIANG Yong Zhong, YANG Hong Mei, JIANG Hong Lin, LYU Jing, MAO Ling Feng
	      	</author>
	    </item>
    	    <item>
	       	<title>Characterization of the CpsQ Regulon Reveals Its Role in the Transcription of Type VI Secretion System 2 Genes in &amp;lt;i&amp;lt;Vibrio parahaemolyticus&amp;lt;/i&amp;lt;</title>
	      	<link>//article/id/eba76245-add3-49f5-80f5-85dd9e3be067</link>
	     	<description><![CDATA[]]></description>
	      	<volume>37</volume>
	      	<issue>4</issue>
	      	<startPage>436</startPage>
	      	<endPage>439</endPage>
	      	<author>
				LUO Xi, LI Xue, ZHANG Miao Miao, HUANG Qing Lian, ZHANG Yi Quan, JI Shen Jie, LU Ren Fei
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    	    <item>
	       	<title>Therapeutic Effect of &amp;lt;i&amp;lt;Rhodopseudomonas palustris&amp;lt;/i&amp;lt;–Bioconverted Extract of &amp;lt;i&amp;lt;Lycium barbarum&amp;lt;/i&amp;lt; on Rats with Lead Exposure</title>
	      	<link>//article/id/66176624-d656-46f7-add3-7b19e88ee6ea</link>
	     	<description><![CDATA[]]></description>
	      	<volume>37</volume>
	      	<issue>4</issue>
	      	<startPage>440</startPage>
	      	<endPage>444</endPage>
	      	<author>
				YANG Hong, SUN Yi, CHAI Shu Tong, LIANG Yan Hui, LIU Ya Ni, YANG Guan E
	      	</author>
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