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      <title>Biomedical and Environmental Sciences</title>
    <link>/</link>
    <description><![CDATA[《Biomedical and Environmental Sciences》2024年第10期]]></description>
    <year><![CDATA[2024]]></year>
    <volume><![CDATA[37]]></volume>
    <issue><![CDATA[10]]></issue>
    	    <item>
	       	<title>2024-10 Cover</title>
	      	<link>//article/id/fc564981-8e07-4bd6-bb4b-31dd370002c9</link>
	     	<description><![CDATA[]]></description>
	      	<volume>37</volume>
	      	<issue>10</issue>
	      	<startPage></startPage>
	      	<endPage></endPage>
	      	<author>
				
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    	    <item>
	       	<title>2024-10 Contents</title>
	      	<link>//article/id/41e306e2-de32-4585-b8dd-0e4ef71b3284</link>
	     	<description><![CDATA[]]></description>
	      	<volume>37</volume>
	      	<issue>10</issue>
	      	<startPage>1</startPage>
	      	<endPage>2</endPage>
	      	<author>
				
	      	</author>
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    	    <item>
	       	<title>Association between Metal(loid) Exposure and Risk of Polycystic Ovary Syndrome Mediated by Anti-Müllerian Hormone among Women Undergoing &amp;lt;i&amp;lt;In Vitro&amp;lt;/i&amp;lt; Fertilization and Embryo Transfer</title>
	      	<link>//article/id/8a9f0976-4954-4096-9a4d-5b0314699b25</link>
	     	<description><![CDATA[&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Objective&amp;lt;/b&amp;lt;  &amp;nbsp;To investigate the relationship and potential pathways between metal(loid) exposure and the risk of polycystic ovary syndrome (PCOS) in women of childbearing age. &amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Methods&amp;lt;/b&amp;lt;  &amp;nbsp;This case-control study included 200 patients with PCOS (cases) and 896 non-PCOS controls with the age of 25–37 years. The concentrations of 29 metal(loid)s in the follicular fluid (FF) and clinical indicators in the serum were measured in all participants. Logistic regression analysis and mediation analysis were conducted to evaluate the associations between metal(loid) exposure and PCOS risk and investigate the possible roles of clinical indicators, respectively. &amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Results&amp;lt;/b&amp;lt;  &amp;nbsp;Logistic regression analysis revealed an association between high copper levels in FF and increased PCOS risk (highest &amp;lt;i&amp;lt;vs.&amp;lt;/i&amp;lt; lowest quartile: adjusted odds ratio = 2.94, 95% confidence interval: 1.83–4.72). A high luteinizing hormone/follicle-stimulating hormone ratio and elevated levels of testosterone and anti-Müllerian hormone (AMH) were strongly associated with increased PCOS risk induced by high copper exposure. The mediation analysis indicated a mediating effect of AMH in the association between copper exposure and PCOS risk. &amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Conclusion&amp;lt;/b&amp;lt;  &amp;nbsp;Copper may affect PCOS risk through the hypothalamic–pituitary–ovarian axis, mediated by AMH. Copper exposure and internal AMH levels are important indicators for early warning of PCOS development.&amp;lt;/sec&amp;lt;]]></description>
	      	<volume>37</volume>
	      	<issue>10</issue>
	      	<startPage>1107</startPage>
	      	<endPage>1116</endPage>
	      	<author>
				Shu Su, Mengyuan Ren, Yanqiu Feng, Changxin Lan, Lailai Yan, Qun Lu, Jia Xu, Bin Han, Lili Zhuang, Mingliang Fang, Bin Wang, Hongchu Bao, Bo Pan
	      	</author>
	    </item>
    	    <item>
	       	<title>Simulated Microgravity can Promote the Apoptosis and Change Inflammatory State of Kupffer Cells</title>
	      	<link>//article/id/049782ae-af32-410a-a951-50de486f65bf</link>
	     	<description><![CDATA[&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Objective&amp;lt;/b&amp;lt;  &amp;nbsp;In this study, we analyzed the transcriptome sequences of Kupffer cells exposed to simulated microgravity for 3 d and conducted biological experiments to determine how microgravity initiates apoptosis in Kupffer cells.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Methods&amp;lt;/b&amp;lt;  &amp;nbsp;Rotary cell culture system was used to construct a simulated microgravity model. GO and KEGG analyses were conducted using the DAVID database. GSEA was performed using the R language. The STRING database was used to conduct PPI analysis. qPCR was used to measure the &amp;lt;i&amp;lt;IL1B, TNFA, CASP3&amp;lt;/i&amp;lt;, &amp;lt;i&amp;lt;CASP9,&amp;lt;/i&amp;lt; and &amp;lt;i&amp;lt;BCL2L11&amp;lt;/i&amp;lt; mRNA expressions&amp;lt;i&amp;lt;.&amp;lt;/i&amp;lt; Western Blotting was performed to detect the level of proteins CASP3 and CASP 9. Flow cytometry was used to detect apoptosis and mitochondrial membrane cells. Transmission electron microscopy was used to detect changes in the ultrastructure of Kupffer cells.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Results&amp;lt;/b&amp;lt;  &amp;nbsp;Transcriptome Sequencing indicated that simulated microgravity affected apoptosis and the inflammatory state of Kupffer cells. Simulated microgravity improved the &amp;lt;i&amp;lt;CASP3&amp;lt;/i&amp;lt;, &amp;lt;i&amp;lt;CASP9,&amp;lt;/i&amp;lt; and &amp;lt;i&amp;lt;BCL2L11&amp;lt;/i&amp;lt; expressions in Kupffer cells. Annexin-V/ PI and JC-1 assays showed that simulated microgravity promoted apoptosis in Kupffer cells. Simulated microgravity causes M1 polarization in Kupffer cells.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Conclusion&amp;lt;/b&amp;lt;  &amp;nbsp;Our study found that simulated microgravity facilitated the apoptosis of Kupffer cells through the mitochondrial pathway and activated Kupffer cells into M1 polarization, which can secrete TNFA to promote apoptosis.&amp;lt;/sec&amp;lt;]]></description>
	      	<volume>37</volume>
	      	<issue>10</issue>
	      	<startPage>1117</startPage>
	      	<endPage>1127</endPage>
	      	<author>
				Jun Ge, Fei Liu, Hongyun Nie, Yuan Yue, Kaige Liu, Haiguan Lin, Hao Li, Tao Zhang, Hongfeng Yan, Bingxin Xu, Hongwei Sun, Jianwu Yang, Shaoyan Si, Jinlian Zhou, Yan Cui
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    	    <item>
	       	<title>Mito-TEMPO Ameliorates Sodium Palmitate Induced Ferroptosis in MIN6 Cells through PINK1/Parkin-Mediated Mitophagy</title>
	      	<link>//article/id/cabe9560-1e59-4001-8ee2-caeba4572b03</link>
	     	<description><![CDATA[&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Objective&amp;lt;/b&amp;lt;  &amp;nbsp; Mitochondrial reactive oxygen species (mtROS) could cause damage to pancreatic β-cells, rendering them susceptible to oxidative damage. Hence, investigating the potential of the mitochondria-targeted antioxidant (Mito-TEMPO) to protect pancreatic β-cells from ferroptosis by mitigating lipid peroxidation becomes crucial.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Methods&amp;lt;/b&amp;lt;  &amp;nbsp; MIN6 cells were cultured &amp;lt;i&amp;lt;in&amp;lt;/i&amp;lt; &amp;lt;i&amp;lt;vitro&amp;lt;/i&amp;lt; with 100 μmol/L sodium palmitate (SP) to simulate diabetes. FerroOrange was utilized for the detection of Fe&amp;lt;sup&amp;lt;2+&amp;lt;/sup&amp;lt; fluorescence staining, BODIPY581/591C11 for lipid reactive oxygen species, and MitoSox-Red for mtROS. Alterations in mitophagy levels were assessed through the co-localization of lysosomal and mitochondrial fluorescence. Western blotting was employed to quantify protein levels of Acsl4, GPX4, FSP1, FE, PINK1, Parkin, TOMM20, P62, and LC3. Subsequently, interventions were implemented using Mito-TEMPO and Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) to observe changes in ferroptosis and mitophagy within MIN6 cells.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Results&amp;lt;/b&amp;lt;  &amp;nbsp; We found that SP induced a dose-dependent increase in Fe&amp;lt;sup&amp;lt;2+&amp;lt;/sup&amp;lt; and lipid ROS in MIN6 cells while decreasing the expression levels of GPX4 and FSP1 proteins. Through bioinformatics analysis, it has been uncovered that mitophagy assumes a crucial role within the ferroptosis pathway associated with diabetes. Additionally, SP decreased the expression of mitophagy-related proteins PINK1 and Parkin, leading to mtROS overproduction. Conversely, Mito-TEMPO effectively eliminated mtROS while activating the mitophagy pathways involving PINK1 and Parkin, thereby reducing the occurrence of ferroptosis in MIN6 cells. CCCP also demonstrated efficacy in reducing ferroptosis in MIN6 cells.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Conclusion&amp;lt;/b&amp;lt;  &amp;nbsp; In summary, Mito-TEMPO proved effective in attenuating mtROS production and initiating mitophagy pathways mediated by PINK1 and Parkin in MIN6 cells. Consequently, this decreased iron overload and lipid peroxidation, ultimately safeguarding the cells from ferroptosis.&amp;lt;/sec&amp;lt;]]></description>
	      	<volume>37</volume>
	      	<issue>10</issue>
	      	<startPage>1128</startPage>
	      	<endPage>1141</endPage>
	      	<author>
				Baolei Chang, Yanyu Su, Tingting Li, Yanxia Zheng, Ruirui Yang, Heng Lu, Hao Wang, Yusong Ding
	      	</author>
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    	    <item>
	       	<title>Marital Status as a Moderator: Exploring the Relationship between Social Engagement and Depressive Symptoms in China’s Older Adult Population</title>
	      	<link>//article/id/b340abd0-62d0-4675-a93a-93185eb63d1e</link>
	     	<description><![CDATA[&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Objective&amp;lt;/b&amp;lt;  &amp;nbsp;This study aims to explore the complex relationship between social engagement and depressive symptoms among older adults in China, focusing particularly on the moderating role of marital status.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Methods&amp;lt;/b&amp;lt;  &amp;nbsp;This study used data from the latest Chinese Longitudinal Healthy Longevity Survey (CLHLS). The analysis used the latent class analysis to delineate personality clusters and hierarchical linear regression, supplemented by the PROCESS macro, to investigate the effects of social engagement and marital status on depressive symptoms.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Results&amp;lt;/b&amp;lt;  &amp;nbsp;The analysis encompassed 7,789 respondents (mean age: 82.53 [&amp;lt;i&amp;lt;s&amp;lt;/i&amp;lt; = 11.20] years), with 54% female. The personality analysis categorized participants into four clusters, with the majority (77.60%) classified as Confident Idealists, who exhibited the lowest levels of depressive symptoms. Hierarchical linear regression analysis yielded several significant findings: Higher levels of social engagement were significantly associated with fewer depressive symptoms (&amp;lt;i&amp;lt;t&amp;lt;/i&amp;lt; = –7.932, &amp;lt;i&amp;lt;P&amp;lt;/i&amp;lt; &amp;lt; 0.001, &amp;lt;i&amp;lt;B&amp;lt;/i&amp;lt; = –0.463). Marital status was a significant factor; married individuals reported fewer depressive symptoms compared to their unmarried counterparts (&amp;lt;i&amp;lt;t&amp;lt;/i&amp;lt; = –6.368, &amp;lt;i&amp;lt;P&amp;lt;/i&amp;lt; &amp;lt; 0.001, &amp;lt;i&amp;lt;B&amp;lt;/i&amp;lt; = –0.750). There was a significant moderating effect of marital status on the relationship between social engagement and depressive symptoms (&amp;lt;i&amp;lt;t&amp;lt;/i&amp;lt; = –2.092, &amp;lt;i&amp;lt;P&amp;lt;/i&amp;lt; = 0.037, &amp;lt;i&amp;lt;B&amp;lt;/i&amp;lt; = –0.217).&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Conclusion&amp;lt;/b&amp;lt;  &amp;nbsp;This study demonstrates that, among Chinese older adults, both social engagement and marital status significantly influence depressive symptoms. Higher social engagement, particularly in other activities like doing household chores, gardening, reading newspapers or books, and playing cards or Mahjong, is associated with fewer depressive symptoms, especially among married individuals.&amp;lt;/sec&amp;lt;]]></description>
	      	<volume>37</volume>
	      	<issue>10</issue>
	      	<startPage>1142</startPage>
	      	<endPage>1157</endPage>
	      	<author>
				Jianlun Wu, Yaping Ye, Man Zhang, Ruichen Cong, Yitao Chen, Pengfei Yu, Qing Guo
	      	</author>
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    	    <item>
	       	<title>The Effect of Blood Lipid Profiles on Chronic Kidney Disease in a Prospective Cohort: Based on a Regression Discontinuity Design</title>
	      	<link>//article/id/29739df1-8bbc-4929-81b2-90958537b86d</link>
	     	<description><![CDATA[&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Objective&amp;lt;/b&amp;lt;  &amp;nbsp; Previous studies on the association between lipid profiles and chronic kidney disease (CKD) have yielded inconsistent results and no defined thresholds for blood lipids.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Methods&amp;lt;/b&amp;lt;  &amp;nbsp; A prospective cohort study including 32,351 subjects who completed baseline and follow-up surveys over 5 years was conducted. Restricted cubic splines and Cox models were used to examine the association between the lipid profiles and CKD. A regression discontinuity design was used to determine the cutoff value of lipid profiles that was significantly associated with increased the risk of CKD.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Results&amp;lt;/b&amp;lt;  &amp;nbsp; Over a median follow-up time of 2.2 (0.5, 4.2) years, 648 (2.00%) subjects developed CKD. The lipid profiles that were significantly and linearly related to CKD included total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), TC/HDL-C, and TG/HDL-C, whereas low-density lipoprotein cholesterol (LDL-C) and LDL-C/HDL-C were nonlinearly correlated with CKD. TC, TG, TC/HDL-C, and TG/HDL-C showed an upward jump at the cutoff value, increasing the risk of CKD by 0.90%, 1.50%, 2.30%, and 1.60%, respectively, whereas HDL-C showed a downward jump at the cutoff value, reducing this risk by 1.0%. Female and participants with dyslipidemia had a higher risk of CKD, while the cutoff values for the different characteristics of the population were different.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Conclusion&amp;lt;/b&amp;lt;  &amp;nbsp; There was a significant association between lipid profiles and CKD in a prospective cohort from Northwest China, while TG, TC/HDL-C, and TG/HDL-C showed a stronger risk association. The specific cutoff values of lipid profiles may provide a clinical reference for screening or diagnosing CKD risk.&amp;lt;/sec&amp;lt;]]></description>
	      	<volume>37</volume>
	      	<issue>10</issue>
	      	<startPage>1158</startPage>
	      	<endPage>1172</endPage>
	      	<author>
				Kang Lyu, Shaodong Liu, Yanli Liu, Jinlong You, Xue Wang, Min Jiang, Chun Yin, Desheng Zhang, Yana Bai, Minzhen Wang, Shan Zheng
	      	</author>
	    </item>
    	    <item>
	       	<title>Spatial Heterogeneity and Risk Factors of Dental Caries in 12-Year-Old Children in Shanxi Province, China</title>
	      	<link>//article/id/4fac22ae-9a6f-400a-96dd-e54b749d217e</link>
	     	<description><![CDATA[&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Objective&amp;lt;/b&amp;lt;  &amp;nbsp; This study aimed to explore the spatial heterogeneity and risk factors for dental caries in 12-year-old children in Shanxi province, China.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Methods&amp;lt;/b&amp;lt;  &amp;nbsp; The data encompassed 3,721 participants from the two most recent oral health surveys conducted across 16 districts in Shanxi Province in 2015 and 2018. Eighteen specific variables were analyzed to examine the interplay between socioeconomic factors, medical resources and environmental conditions. The Geo-detector model was employed to assess the impacts and interactions of these ecological factors.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Results&amp;lt;/b&amp;lt;  &amp;nbsp; Socioeconomic factors (&amp;lt;i&amp;lt;Q&amp;lt;/i&amp;lt; = 0.30, &amp;lt;i&amp;lt;P&amp;lt;/i&amp;lt; &amp;lt; 0.05) exhibited a more substantial impact compared to environmental (&amp;lt;i&amp;lt;Q&amp;lt;/i&amp;lt; = 0.19, &amp;lt;i&amp;lt;P&amp;lt;/i&amp;lt; &amp;lt; 0.05) and medical resource factors (&amp;lt;i&amp;lt;Q&amp;lt;/i&amp;lt; = 0.25, &amp;lt;i&amp;lt;P&amp;lt;/i&amp;lt; &amp;lt; 0.05). Notably, the urban population percentage (UPP) demonstrated the most significant explanatory power for the spatial heterogeneity in caries prevalence, as denoted by its highest &amp;lt;i&amp;lt;q&amp;lt;/i&amp;lt;-value (&amp;lt;i&amp;lt;q&amp;lt;/i&amp;lt; = 0.51, &amp;lt;i&amp;lt;P&amp;lt;/i&amp;lt; &amp;lt; 0.05). Additionally, the spatial distribution’s heterogeneity of caries was significantly affected by SO&amp;lt;sub&amp;lt;2&amp;lt;/sub&amp;lt; concentration (&amp;lt;i&amp;lt;q&amp;lt;/i&amp;lt; = 0.39, &amp;lt;i&amp;lt;P&amp;lt;/i&amp;lt; &amp;lt; 0.05) and water fluoride levels (&amp;lt;i&amp;lt;q&amp;lt;/i&amp;lt; = 0.27, &amp;lt;i&amp;lt;P&amp;lt;/i&amp;lt; &amp;lt; 0.05) among environmental factors.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Conclusion&amp;lt;/b&amp;lt;  &amp;nbsp; The prevalence of caries exhibited spatial heterogeneity, escalating from North to South in Shanxi Province, China, influenced by socioeconomic factors, medical resources, and environmental conditions to varying extents.&amp;lt;/sec&amp;lt;]]></description>
	      	<volume>37</volume>
	      	<issue>10</issue>
	      	<startPage>1173</startPage>
	      	<endPage>1183</endPage>
	      	<author>
				Ruxia Hou, Tingting Yang, Jiajia Liu, Hao Chen, Wen Kang, Junming Li, Xiaotong Shi, Yi Liang, Junyu Liu, Bin Zhao, Xiangyu Wang
	      	</author>
	    </item>
    	    <item>
	       	<title>Association between Residential Greenness and Cardiometabolic Risk Factors among Adults in Rural Xinjiang Uygur Autonomous Region, China: A Cross-Sectional Study</title>
	      	<link>//article/id/ecd0c726-229a-4dca-aba7-8ed22ba8ec1b</link>
	     	<description><![CDATA[&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Objective&amp;lt;/b&amp;lt;  &amp;nbsp;This study aimed to explore the relationships between residential greenness and cardiometabolic risk factors among rural adults in Xinjiang Uygur Autonomous Region (Xinjiang) and thus provide a theoretical basis and data support for improving the health of residents in this region.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Methods&amp;lt;/b&amp;lt;  &amp;nbsp;We recruited 9,723 adult rural residents from the 51st Regiment of the Third Division of the Xinjiang Production and Construction Corps in September 2016. The normalized difference vegetation index (NDVI) was used to estimate residential greenness. The generalized linear mixed model (GLMM) was used to examine the association between residential greenness and cardiometabolic risk factors.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Results&amp;lt;/b&amp;lt;  &amp;nbsp;Higher residential greenness was associated with lower cardiometabolic risk factor prevalence. After adjustments were made for age, sex, education, and marital status, for each interquartile range (IQR) increase of NDVI&amp;lt;sub&amp;lt;500-m&amp;lt;/sub&amp;lt;, the risk of hypertension was reduced by 10.3% (&amp;lt;i&amp;lt;OR&amp;lt;/i&amp;lt; = 0.897, 95% &amp;lt;i&amp;lt;CI&amp;lt;/i&amp;lt; = 0.836–0.962), the risk of obesity by 20.5% (&amp;lt;i&amp;lt;OR&amp;lt;/i&amp;lt; = 0.795, 95% &amp;lt;i&amp;lt;CI&amp;lt;/i&amp;lt; = 0.695–0.910), the risk of type 2 diabetes by 15.1% (&amp;lt;i&amp;lt;OR&amp;lt;/i&amp;lt; = 0.849, 95% &amp;lt;i&amp;lt;CI&amp;lt;/i&amp;lt; = 0.740–0.974), and the risk of dyslipidemia by 10.5% (&amp;lt;i&amp;lt;OR&amp;lt;/i&amp;lt; = 0.895, 95% &amp;lt;i&amp;lt;CI&amp;lt;/i&amp;lt; = 0.825–0.971). Risk factor aggregation was reduced by 20.4% (&amp;lt;i&amp;lt;OR&amp;lt;/i&amp;lt; = 0.796, 95% &amp;lt;i&amp;lt;CI&amp;lt;/i&amp;lt; = 0.716–0.885) for the same. Stratified analysis showed that NDVI&amp;lt;sub&amp;lt;500-m&amp;lt;/sub&amp;lt; was associated more strongly with hypertension, dyslipidemia, and risk factor aggregation among male participants. The association of NDVI&amp;lt;sub&amp;lt;500-m&amp;lt;/sub&amp;lt; with type 2 diabetes was stronger among participants with a higher education level. PM&amp;lt;sub&amp;lt;10&amp;lt;/sub&amp;lt; and physical activity mediated 1.9%–9.2% of the associations between NDVI&amp;lt;sub&amp;lt;500-m&amp;lt;/sub&amp;lt; and obesity, dyslipidemia, and risk factor aggregation.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Conclusion&amp;lt;/b&amp;lt;  &amp;nbsp;Higher residential greenness has a protective effect against cardiometabolic risk factors among rural residents in Xinjiang. Increasing the area of green space around residences is an effective measure to reduce the burden of cardiometabolic-related diseases among rural residents in Xinjiang.&amp;lt;/sec&amp;lt;]]></description>
	      	<volume>37</volume>
	      	<issue>10</issue>
	      	<startPage>1184</startPage>
	      	<endPage>1194</endPage>
	      	<author>
				Leyao Jian, Bo Yang, Rulin Ma, Shuxia Guo, Jia He, Yu Li, Yusong Ding, Dongsheng Rui, Yidan Mao, Xin He, Xueying Sun, Shengyu Liao, Heng Guo
	      	</author>
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    	    <item>
	       	<title>Efficacy and Safety of Combined Bedaquiline and Delamanid Use among Patients with Multidrug-Resistant Tuberculosis in Beijing, China</title>
	      	<link>//article/id/e37926f1-d98d-48c4-986d-ab81df189595</link>
	     	<description><![CDATA[&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Objectives&amp;lt;/b&amp;lt;  &amp;nbsp;The combined use of bedaquiline and delamanid (BDQ-DLM) is limited by an increased risk of prolonging the QTc interval. We retrospectively evaluated patients who received DLM/BDQ-containing regimens at a TB-specialized hospital. We aimed to present clinical efficacy and safety data for Chinese patients.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Methods&amp;lt;/b&amp;lt;  &amp;nbsp;This case–control study included patients with multidrug-resistant tuberculosis (MDR-TB) treated with BDQ alone or BDQ plus DLM.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Results&amp;lt;/b&amp;lt;  &amp;nbsp;A total of 96 patients were included in this analysis: 64 in the BDQ group and 32 in the BDQ + DLM group. Among the 96 patients with positive sputum culture at the initiation of BDQ alone or BDQ combined with DLM, 46 patients (71.9%) in the BDQ group and 29 (90.6%) in the BDQ-DLM group achieved sputum culture conversion during treatment. The rate of sputum culture conversion did not differ between the two groups. The time to sputum culture conversion was significantly shorter in the BDQ-DLM group than in the BDQ group. The most frequent adverse event was QTc interval prolongation; however, the frequency of adverse events did not differ between the groups.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp;  &amp;lt;b&amp;lt;Conclusion&amp;lt;/b&amp;lt;  &amp;nbsp;In conclusion, our results demonstrate that the combined use of BDQ and DLM is efficacious and tolerable in Chinese patients infected with MDR-TB. Patients in the BDQ-DLM group achieved sputum culture conversion sooner than those in the BDQ group.&amp;lt;/sec&amp;lt;]]></description>
	      	<volume>37</volume>
	      	<issue>10</issue>
	      	<startPage>1195</startPage>
	      	<endPage>1203</endPage>
	      	<author>
				Can Guo, Lihui Nie, Yanhua Song, Rongmei Liu, Xiaoguang Wu, Yuanyuan Shang, Xuxia Zhang, Yu Pang, Mengqiu Gao
	      	</author>
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    	    <item>
	       	<title>Endometrial Cancer Research Based on Gut Microbiomics and Metabolomics: An Analysis of Correlation and Differences</title>
	      	<link>//article/id/57853484-32de-4794-a4f0-d3767c92e31c</link>
	     	<description><![CDATA[]]></description>
	      	<volume>37</volume>
	      	<issue>10</issue>
	      	<startPage>1204</startPage>
	      	<endPage>1207</endPage>
	      	<author>
				Dan Xu, Fengqin Xue, Ruifang Zhai, Sanyuan Zhang, Zhe Wang, Peiyue Yu
	      	</author>
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	      	<link>//article/id/d13c6f3e-8bf4-4cc9-898d-705f0b13c91f</link>
	     	<description><![CDATA[]]></description>
	      	<volume>37</volume>
	      	<issue>10</issue>
	      	<startPage>1208</startPage>
	      	<endPage>1212</endPage>
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	     	<description><![CDATA[]]></description>
	      	<volume>37</volume>
	      	<issue>10</issue>
	      	<startPage>1213</startPage>
	      	<endPage>1220</endPage>
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	     	<description><![CDATA[]]></description>
	      	<volume>37</volume>
	      	<issue>10</issue>
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	     	<description><![CDATA[]]></description>
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	      	<issue>10</issue>
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