<?xml version="1.0" standalone="yes"?>
<rss version="2.0">
  <channel>
      <title>Biomedical and Environmental Sciences</title>
    <link>/</link>
    <description><![CDATA[《Biomedical and Environmental Sciences》2022年第1期]]></description>
    <year><![CDATA[2022]]></year>
    <volume><![CDATA[35]]></volume>
    <issue><![CDATA[1]]></issue>
    	    <item>
	       	<title>Contents</title>
	      	<link>//article/id/fe6ff91a-bb1c-40fb-91a7-2fbbeeea10eb</link>
	     	<description><![CDATA[]]></description>
	      	<volume>35</volume>
	      	<issue>1</issue>
	      	<startPage>1</startPage>
	      	<endPage>2</endPage>
	      	<author>
				
	      	</author>
	    </item>
    	    <item>
	       	<title>Cover</title>
	      	<link>//article/id/fcbf4e95-56aa-47a8-9b8e-2993388d1914</link>
	     	<description><![CDATA[]]></description>
	      	<volume>35</volume>
	      	<issue>1</issue>
	      	<startPage>1</startPage>
	      	<endPage>1</endPage>
	      	<author>
				
	      	</author>
	    </item>
    	    <item>
	       	<title>Physical Activity Guidelines for Chinese (2021)</title>
	      	<link>//article/id/50de3078-61dc-4cdc-a2fc-179687f15df2</link>
	     	<description><![CDATA[]]></description>
	      	<volume>35</volume>
	      	<issue>1</issue>
	      	<startPage>1</startPage>
	      	<endPage>3</endPage>
	      	<author>
				Composing and Editorial Board of Physical Activity Guidelines for Chinese
	      	</author>
	    </item>
    	    <item>
	       	<title>Association between the Neutrophil-to-lymphocyte Ratio and New-onset Subclinical Macrovascular and Microvascular Diseases in the Chinese Population</title>
	      	<link>//article/id/aef9d6e2-36dc-4253-a84d-d90577ee84d4</link>
	     	<description><![CDATA[&amp;lt;sec&amp;lt;&amp;nbsp; &amp;lt;b&amp;lt;Objective&amp;lt;/b&amp;lt; &amp;nbsp;The association between neutrophil-to-lymphocyte ratio (NLR) with subclinical macrovascular and microvascular diseases has been less investigated. We sought to examine the association between NLR and new-onset subclinical macrovascular and microvascular abnormalities in the Chinese population. &amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp; &amp;lt;b&amp;lt;Methods&amp;lt;/b&amp;lt; &amp;nbsp;From a community cohort, we included 6,430 adults aged ≥ 40 years without subclinical macrovascular and microvascular diseases at baseline. We measured subclinical macrovascular and microvascular abnormalities separately using the ankle-brachial index (ABI), brachial-ankle pulse wave velocity (baPWV), and albuminuria. &amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp; &amp;lt;b&amp;lt;Results&amp;lt;/b&amp;lt; &amp;nbsp;During a mean follow-up of 4.3 years, 110 participants developed incident abnormal ABI, 746 participants developed incident elevated baPWV, and 503 participants developed incident albuminuria. Poisson regression analysis indicated that NLR was significantly associated with an increased risk of new-onset abnormal ABI, elevated baPWV, and albuminuria. Compared to overweight/obese participants, we found a much stronger association between NLR and subclinical vascular abnormalities in participants with normal weight. Furthermore, we found an interaction between the NLR and body mass index (BMI) on the risk of new-onset abnormal ABI (&amp;lt;i&amp;lt;P&amp;lt;/i&amp;lt; for interaction: 0.01). &amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp; &amp;lt;b&amp;lt;Conclusion&amp;lt;/b&amp;lt; &amp;nbsp;NLR was associated with subclinical macrovascular and microvascular diseases in the Chinese population. Furthermore, in participants with normal weight, the association between NLR and subclinical vascular abnormalities was much stronger.&amp;lt;/sec&amp;lt;]]></description>
	      	<volume>35</volume>
	      	<issue>1</issue>
	      	<startPage>4</startPage>
	      	<endPage>12</endPage>
	      	<author>
				WANG Jia Lu, CAO Qiu Yu, XIN Zhuo Jun, LIU Shan Shan, XU Min, WANG Tian Ge, LU Jie Li, CHEN Yu Hong, WANG Shuang Yuan, ZHAO Zhi Yun, XU Yu, NING Guang, WANG Wei Qing, BI Yu Fang, LI Mian
	      	</author>
	    </item>
    	    <item>
	       	<title>Joint Association of Metabolic Health and Obesity with Ten-Year Risk of Cardiovascular Disease among Chinese Adults</title>
	      	<link>//article/id/e5e9a90b-59a0-493e-8378-17b1d17a9a6e</link>
	     	<description><![CDATA[&amp;lt;sec&amp;lt;&amp;nbsp; &amp;lt;b&amp;lt;Objective&amp;lt;/b&amp;lt; &amp;nbsp;This study aims to investigate the association of metabolic phenotypes that are jointly determined by body mass index (BMI) or fat mass percentage and metabolic health status with the ten-year risk of cardiovascular disease (CVD) among Chinese adults. &amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp; &amp;lt;b&amp;lt;Methods&amp;lt;/b&amp;lt; &amp;nbsp;Data were obtained from a cross-sectional study. BMI and body fat mass percentage (FMP) combined with the metabolic status were used to define metabolic phenotypes. Multiple linear regression and logistic regression were used to examine the effects of metabolic phenotypes on CVD risk. &amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp; &amp;lt;b&amp;lt;Results&amp;lt;/b&amp;lt; &amp;nbsp;A total of 13,239 adults aged 34–75 years were included in this study. Compared with the metabolically healthy non-obese (MHNO) phenotype, the metabolically unhealthy non-obese (MUNO) and metabolically unhealthy obese (MUO) phenotypes defined by BMI showed a higher CVD risk [odds ratio, &amp;lt;i&amp;lt;OR&amp;lt;/i&amp;lt; (95% confidence interval, &amp;lt;i&amp;lt;CI&amp;lt;/i&amp;lt;): 2.34 (1.89–2.89), 3.45 (2.50–4.75), respectively], after adjusting for the covariates. The MUNO and MUO phenotypes defined by FMP showed a higher CVD risk [&amp;lt;i&amp;lt;OR&amp;lt;/i&amp;lt; (95% &amp;lt;i&amp;lt;CI&amp;lt;/i&amp;lt;): 2.31 (1.85–2.88), 2.63 (1.98–3.48), respectively] than the MHNO phenotype. The metabolically healthy obese phenotype, regardless of being defined by BMI or FMP, showed no CVD risk compared with the MHNO phenotype. &amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp; &amp;lt;b&amp;lt;Conclusion&amp;lt;/b&amp;lt; &amp;nbsp;General obesity without central obesity does not increase CVD risk in metabolically healthy individuals. FMP might be a more meaningful factor for the evaluation of the association of obesity with CVD risk. Obesity and metabolic status have a synergistic effect on CVD risk.&amp;lt;/sec&amp;lt;]]></description>
	      	<volume>35</volume>
	      	<issue>1</issue>
	      	<startPage>13</startPage>
	      	<endPage>21</endPage>
	      	<author>
				LIU Jun Ting, YAO Hong Yan, YU Shi Cheng, LIU Jian Jun, ZHU Guang Jin, HAN Shao Mei, XU Tao
	      	</author>
	    </item>
    	    <item>
	       	<title>Associations of Daytime Napping with Incident Cardiovascular Diseases and Hypertension in Chinese Adults: A Nationwide Cohort Study</title>
	      	<link>//article/id/e084417d-62e9-4883-b874-1563a89ff7cb</link>
	     	<description><![CDATA[&amp;lt;sec&amp;lt;&amp;nbsp; &amp;lt;b&amp;lt;Objective&amp;lt;/b&amp;lt; &amp;nbsp;&amp;lt;italic/&amp;lt; This study aimed to examine the associations of daytime napping with incident risks of cardiovascular diseases (CVDs) and hypertension (HTN). &amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp; &amp;lt;b&amp;lt;Methods&amp;lt;/b&amp;lt; &amp;nbsp;Data for napping and CVD outcomes in 25 provinces were collected from baseline (2010) and three waves of follow-up (2012–2017) investigations of the China Family Panel Studies. Cox frailty models with random intercepts for the surveyed provinces were used to assess the longitudinal effects of daytime napping on CVD and HTN. &amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp; &amp;lt;b&amp;lt;Results&amp;lt;/b&amp;lt; &amp;nbsp;Compared with non-nappers, 30+ min nappers had higher risks of CVD and HTN, while no significant associations were observed among &amp;lt; 30 min nappers. Incident risks among 30- to &amp;lt; 60-min nappers increased by 22% [hazard ratio (HR) 1.22, 95% confidence interval (&amp;lt;i&amp;lt;CI&amp;lt;/i&amp;lt;) 1.08–1.39] for CVD and 21% (1.21, 1.04–1.41) for HTN, respectively, with corresponding HRs of CVD and HTN of 1.27 (1.09–1.47) and 1.38 (1.16–1.65) among ≥ 60 min nappers. Nap-associated CVD risks varied by subgroups, with stronger associations in participants with lower body mass index (&amp;lt; 24 kg/m&amp;lt;sup&amp;lt;2&amp;lt;/sup&amp;lt;), physically inactive persons, smokers, and participants with longer nighttime sleep (≥ 7 h/night). Significant effects of daytime napping were observed on rural and northern residents only, highlighting great regional variations in CVD risks associated with napping habits. &amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp; &amp;lt;b&amp;lt;Conclusions&amp;lt;/b&amp;lt; &amp;nbsp;This cohort study revealed strong evidence that long daytime napping (≥ 30 min) is associated with an increased incidence of cardiovascular events.&amp;lt;/sec&amp;lt;]]></description>
	      	<volume>35</volume>
	      	<issue>1</issue>
	      	<startPage>22</startPage>
	      	<endPage>34</endPage>
	      	<author>
				WANG Lu, WANG Ke, LIU Lin Jiong, ZHANG Yuan Yuan, SHU Hai Nan, WANG Kai, ZHOU Pei Xuan, ZHANG Yun Quan
	      	</author>
	    </item>
    	    <item>
	       	<title>Single-copy Loss of Rho Guanine Nucleotide Exchange Factor 10 (&amp;lt;i&amp;lt;arhgef10&amp;lt;/i&amp;lt;) Causes Locomotor Abnormalities in Zebrafish Larvae</title>
	      	<link>//article/id/e01b6c8d-d8ca-4e6a-ba71-f3ca5fb95fad</link>
	     	<description><![CDATA[&amp;lt;sec&amp;lt;&amp;nbsp; &amp;lt;b&amp;lt;Objective&amp;lt;/b&amp;lt; &amp;nbsp;To determine if &amp;lt;i&amp;lt;ARHGEF10&amp;lt;/i&amp;lt; has a haploinsufficient effect and provide evidence to evaluate the severity, if any, during prenatal consultation.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp; &amp;lt;b&amp;lt;Methods&amp;lt;/b&amp;lt; &amp;nbsp;Zebrafish was used as a model for generating mutant. The pattern of &amp;lt;i&amp;lt;arhgef10&amp;lt;/i&amp;lt; expression in the early stages of zebrafish development was observed using whole-mount &amp;lt;i&amp;lt;in situ&amp;lt;/i&amp;lt; hybridization (WISH). CRISPR/Cas9 was applied to generate a zebrafish model with a single-copy or homozygous &amp;lt;i&amp;lt;arhgef10&amp;lt;/i&amp;lt; deletion. Activity and light/dark tests were performed in &amp;lt;i&amp;lt;arhgef10&amp;lt;/i&amp;lt;&amp;lt;sup&amp;lt;−/−&amp;lt;/sup&amp;lt;, &amp;lt;i&amp;lt;arhgef10&amp;lt;/i&amp;lt;&amp;lt;sup&amp;lt;+/−&amp;lt;/sup&amp;lt;, and wild-type zebrafish larvae. &amp;lt;i&amp;lt;ARHGEF10&amp;lt;/i&amp;lt; was knocked down using small interferon RNA (siRNA) in the SH-SY5Y cell line, and cell proliferation and apoptosis were determined using the CCK-8 assay and Annexin V/PI staining, respectively.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp; &amp;lt;b&amp;lt;Results&amp;lt;/b&amp;lt; &amp;nbsp;WISH showed that during zebrafish embryonic development&amp;lt;i&amp;lt; arhgef10&amp;lt;/i&amp;lt; was expressed in the midbrain and hindbrain at 36–72 h post-fertilization (hpf) and in the hemopoietic system at 36–48 hpf. The zebrafish larvae with single-copy and homozygous &amp;lt;i&amp;lt;arhgef10&amp;lt;/i&amp;lt; deletions had lower exercise capacity and poorer responses to environmental changes compared to wild-type zebrafish larvae. Moreover, &amp;lt;i&amp;lt;arhgef&amp;lt;/i&amp;lt;10&amp;lt;sup&amp;lt;−/−&amp;lt;/sup&amp;lt; zebrafish had more severe symptoms than &amp;lt;i&amp;lt;arhgef&amp;lt;/i&amp;lt;10&amp;lt;sup&amp;lt;+/-&amp;lt;/sup&amp;lt; zebrafish. Knockdown of &amp;lt;i&amp;lt;ARHGEF10&amp;lt;/i&amp;lt; in human neuroblastoma cells led to decreased cell proliferation and increased cell apoptosis.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp; &amp;lt;b&amp;lt;Conclusion&amp;lt;/b&amp;lt; &amp;nbsp;Based on our findings, &amp;lt;i&amp;lt;ARHGEF10&amp;lt;/i&amp;lt; appeared to have a haploinsufficiency effect.&amp;lt;/sec&amp;lt;]]></description>
	      	<volume>35</volume>
	      	<issue>1</issue>
	      	<startPage>35</startPage>
	      	<endPage>44</endPage>
	      	<author>
				ZHANG Yi, AN Ming Xing, GONG Chen, LI Yang Yang, WANG Yu Tong, LIN Meng, LI Rong, TIAN Chan
	      	</author>
	    </item>
    	    <item>
	       	<title>Association between Maternal Drug Use and Cytochrome P450 Genetic Polymorphisms and the Risk of Congenital Heart Defects in Offspring</title>
	      	<link>//article/id/e9f0c520-e796-4e0c-9309-1a6e879dd88b</link>
	     	<description><![CDATA[&amp;lt;sec&amp;lt;&amp;nbsp; &amp;lt;b&amp;lt;Objective&amp;lt;/b&amp;lt; &amp;nbsp;This study aimed to assess the associations between maternal drug use, cytochrome P450 (&amp;lt;i&amp;lt;CYP450&amp;lt;/i&amp;lt;) genetic polymorphisms, and their interactions with the risk of congenital heart defects (CHDs) in offspring. &amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp; &amp;lt;b&amp;lt;Methods&amp;lt;/b&amp;lt; &amp;nbsp;A case-control study involving 569 mothers of CHD cases and 652 controls was conducted from November 2017 to January 2020. &amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp; &amp;lt;b&amp;lt;Results&amp;lt;/b&amp;lt; &amp;nbsp;After adjusting for potential confounding factors, the results show that mothers who used ovulatory drugs (adjusted odds ratio [a&amp;lt;i&amp;lt;OR&amp;lt;/i&amp;lt;] = 2.12; 95% confidence interval [&amp;lt;i&amp;lt;CI&amp;lt;/i&amp;lt;]: 1.08–4.16), antidepressants (a&amp;lt;i&amp;lt;OR&amp;lt;/i&amp;lt; = 2.56; 95% &amp;lt;i&amp;lt;CI&amp;lt;/i&amp;lt;: 1.36–4.82), antiabortifacients (a&amp;lt;i&amp;lt;OR&amp;lt;/i&amp;lt; = 1.55; 95% &amp;lt;i&amp;lt;CI&amp;lt;/i&amp;lt;: 1.00–2.40), or traditional Chinese drugs (a&amp;lt;i&amp;lt;OR&amp;lt;/i&amp;lt; = 1.97; 95% &amp;lt;i&amp;lt;CI&amp;lt;/i&amp;lt;: 1.26–3.09) during pregnancy were at a significantly higher risk of CHDs in offspring. Maternal &amp;lt;i&amp;lt;CYP450&amp;lt;/i&amp;lt; genetic polymorphisms at rs1065852 (A/T &amp;lt;i&amp;lt;vs&amp;lt;/i&amp;lt;. A/A: &amp;lt;i&amp;lt;OR&amp;lt;/i&amp;lt; = 1.53, 95% &amp;lt;i&amp;lt;CI&amp;lt;/i&amp;lt;: 1.10–2.14; T/T &amp;lt;i&amp;lt;vs.&amp;lt;/i&amp;lt; A/A: &amp;lt;i&amp;lt;OR&amp;lt;/i&amp;lt; = 1.57, 95% &amp;lt;i&amp;lt;CI&amp;lt;/i&amp;lt;: 1.07–2.31) and rs16947 (G/G &amp;lt;i&amp;lt;vs.&amp;lt;/i&amp;lt; C/C: &amp;lt;i&amp;lt;OR&amp;lt;/i&amp;lt; = 3.41, 95% &amp;lt;i&amp;lt;CI&amp;lt;/i&amp;lt;: 1.82–6.39) were also significantly associated with the risk of CHDs in offspring. Additionally, significant interactions were observed between the &amp;lt;i&amp;lt;CYP450 &amp;lt;/i&amp;lt;genetic variants and drug use on the development of CHDs. &amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt;&amp;nbsp; &amp;lt;b&amp;lt;Conclusions&amp;lt;/b&amp;lt; &amp;nbsp;In those of Chinese descent, ovulatory drugs, antidepressants, antiabortifacients, and traditional Chinese medicines may be associated with the risk of CHDs in offspring. Maternal &amp;lt;i&amp;lt;CYP450&amp;lt;/i&amp;lt; genes may regulate the effects of maternal drug exposure on fetal heart development.&amp;lt;/sec&amp;lt;]]></description>
	      	<volume>35</volume>
	      	<issue>1</issue>
	      	<startPage>45</startPage>
	      	<endPage>57</endPage>
	      	<author>
				QIN Jia Bi, LUO Liu, SUN Meng Ting, HUANG Peng, WANG Ting Ting, ZHANG Sen Mao, LI Jin Qi, LI Yi Huan, CHEN Le Tao, DIAO Jing Yi, ZHU Ping
	      	</author>
	    </item>
    	    <item>
	       	<title>The Effectiveness of Antiviral Treatment in Severe COVID-19 Patients in Wuhan, China: A Multicenter Study</title>
	      	<link>//article/id/50f42b92-cbf2-4fdc-9b5a-344020bbf1d4</link>
	     	<description><![CDATA[]]></description>
	      	<volume>35</volume>
	      	<issue>1</issue>
	      	<startPage>58</startPage>
	      	<endPage>63</endPage>
	      	<author>
				ZHOU Xian Long, DING Guo Yong, YANG Lu Yu, LIU Rui Ning, HOU Hai Feng, WANG Ping, MA Min, HU Zhuan Zhuan, HUANG Lei, XU Xi Zhu, HU Quan, ZHAO Yan, XING Wei Jia, ZHAO Zhi Gang
	      	</author>
	    </item>
    	    <item>
	       	<title>Application of Oral Fluid in Measles IgG Antibody Detection for Medical Staff</title>
	      	<link>//article/id/c5b1c6dd-77c8-4c95-a5c9-b464878ee881</link>
	     	<description><![CDATA[]]></description>
	      	<volume>35</volume>
	      	<issue>1</issue>
	      	<startPage>64</startPage>
	      	<endPage>68</endPage>
	      	<author>
				DONG Mei, SUN Jing Yi, XIE Hui, LIU Jie, WANG Yi Ting, FU Yin, DONG Jian Ping, HUANG Fang
	      	</author>
	    </item>
    	    <item>
	       	<title>Master Quorum Sensing Regulator HapR Acts as A Repressor of the Mannitol Phosphotransferase System Operon in &amp;lt;i&amp;lt;Vibrio cholerae&amp;lt;/i&amp;lt;</title>
	      	<link>//article/id/7877e83f-109a-403b-8a84-9bd49a675149</link>
	     	<description><![CDATA[]]></description>
	      	<volume>35</volume>
	      	<issue>1</issue>
	      	<startPage>69</startPage>
	      	<endPage>72</endPage>
	      	<author>
				ZHANG Yi Quan, MA Li Zhi, GAO Yue, QIN Qin, LI Jie, LOU Jing, ZHANG Miao Miao, XUE Xing Fan, KAN Biao, GAO He
	      	</author>
	    </item>
    	    <item>
	       	<title>Factors Associated with Diagnostic Delay of Pulmonary Tuberculosis in China</title>
	      	<link>//article/id/08b4c8d7-2999-4273-b7ec-1500a3e84ad5</link>
	     	<description><![CDATA[]]></description>
	      	<volume>35</volume>
	      	<issue>1</issue>
	      	<startPage>73</startPage>
	      	<endPage>78</endPage>
	      	<author>
				XU Cai Hong, ZHANG Xiao Meng, LIU Yan, HU Dong Mei, XIA Yin Yin, WANG Li, ZHANG Hui
	      	</author>
	    </item>
    	    <item>
	       	<title>SIRT1 Mediates Sestrin1-Induced Improvement in Hepatic Insulin Resistance</title>
	      	<link>//article/id/1f80e8a6-facd-4852-a697-fad3b478a863</link>
	     	<description><![CDATA[]]></description>
	      	<volume>35</volume>
	      	<issue>1</issue>
	      	<startPage>79</startPage>
	      	<endPage>83</endPage>
	      	<author>
				GENG Chao, XUE Yuan, YANG Jia Hui, GAO Ming Yue, ZHAO Wei, LI Chun Mei, XIE Xiang Hong, ZHANG Wei Hong, ZHANG Hua Bing, FANG Fu De, YAO Hong, LIU Xiao Jun
	      	</author>
	    </item>
    	    <item>
	       	<title>An Analysis on Failure Reasons of Quit Smoking among Smokers in Beijing Communities—Based on a Cross-Sectional Study</title>
	      	<link>//article/id/64629d0a-5b4f-4332-b437-2f9a2e635b81</link>
	     	<description><![CDATA[]]></description>
	      	<volume>35</volume>
	      	<issue>1</issue>
	      	<startPage>84</startPage>
	      	<endPage>88</endPage>
	      	<author>
				JIN Qian Ying, LI Xing Ming, LIU Han, MA Han Qiao, QIAO Kun, Ali Akbar
	      	</author>
	    </item>
    	    <item>
	       	<title>Association of Residential Greenness with the Prevalence of Metabolic Syndrome in a Rural Chinese Population: the Henan Rural Cohort Study</title>
	      	<link>//article/id/3f0db848-d584-49b3-b206-7b2b96b0767f</link>
	     	<description><![CDATA[]]></description>
	      	<volume>35</volume>
	      	<issue>1</issue>
	      	<startPage>89</startPage>
	      	<endPage>94</endPage>
	      	<author>
				HE Ya Ling, LIU Xiao Tian, TU Run Qi, PAN Ming Ming, NIU Miao Miao, CHEN Gong Bo, HOU Jian, MAO Zhen Xing, HUO Wen Qian, LI Shan Shan, GUO Yu Ming, WANG Chong Jian
	      	</author>
	    </item>
          </channel>
</rss>