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  	    <title>Biomedical and Environmental Sciences</title>
    <link>/</link>
    <description><![CDATA[《Biomedical and Environmental Sciences》2018年第12期]]></description>
    <year><![CDATA[2018]]></year>
    <volume><![CDATA[31]]></volume>
    <issue><![CDATA[12]]></issue>
    	    <item>
	       	<title>Prognostic Value of NT-proBNP in Stable Coronary Artery Disease in Chinese Patients after Percutaneous Coronary Intervention in the Drug-eluting Stent Era</title>
	      	<link>//article/id/be5398a8-d777-444f-9486-aea8bb367211</link>
	     	<description><![CDATA[&amp;lt;sec&amp;lt; &amp;lt;b&amp;lt;Objective&amp;lt;/b&amp;lt;  The predictive value of N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with stable coronary artery disease (SCAD) in the drug-eluting stent era is not yet clear. We aimed to evaluate the prognostic value of NT-proBNP in SCAD patients after percutaneous coronary intervention (PCI).&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt; &amp;lt;b&amp;lt;Methods&amp;lt;/b&amp;lt;  We examined 4, 293 consecutive SCAD patients who underwent PCI between January 2013 and December 2013 in Fuwai Hospital, China. The primary endpoint was all-cause death. NT-proBNP levels were measured before PCI using Elisa kits (Biomedica, Austria). The indication for PCI was based on the degree of coronary stenosis and evidence of ischemia.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt; &amp;lt;b&amp;lt;Results&amp;lt;/b&amp;lt;  Among 3, 187 SCAD patients with NT-proBNP data, after a 2-year follow-up, NT-proBNP levels were predictive for all-cause death in the SCAD population[area under the receiver operating characteristic curve, 0.768; 95% confidence interval (&amp;lt;i&amp;lt;CI&amp;lt;/i&amp;lt;), 0.687-0.849; &amp;lt;i&amp;lt;P&amp;lt;/i&amp;lt; &amp;lt; 0.001]. At the optimum cutoff point of 732 pg/mL, the sensitivity and specificity of death was 75.0% and 72.3%, respectively. In a multivariable Cox regression model, the death hazard ratio was 6.43 (95% &amp;lt;i&amp;lt;CI&amp;lt;/i&amp;lt;, 2.99-13.82; &amp;lt;i&amp;lt;P&amp;lt;/i&amp;lt; &amp;lt; 0.001) for patients with NT-proBNP levels ≥ 732 pg/mL, compared with &amp;lt; 732 pg/mL.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt; &amp;lt;b&amp;lt;Conclusion&amp;lt;/b&amp;lt;  NT-proBNP is a strong predictor of 2-year death with SCAD after PCI in the drug-eluting stent era.&amp;lt;/sec&amp;lt;]]></description>
	      	<volume>31</volume>
	      	<issue>12</issue>
	      	<startPage>859</startPage>
	      	<endPage>866</endPage>
	      	<author>
				Xue Yan ZHAO, Jian Xin LI, Xiao Fang TANG, Jing Jing XU, Ying SONG, Lin JIANG, Jue CHEN, Lei SONG, Li Jian GAO, Zhan GAO, Shu Bin QIAO, Yue Jin YANG, Run Lin GAO, Bo XU, Jin Qing YUAN
	      	</author>
	    </item>
    	    <item>
	       	<title>Coxsackievirus B3 Infection Triggers Autophagy through 3 Pathways of Endoplasmic Reticulum Stress</title>
	      	<link>//article/id/5e6f095a-2157-4d18-a4d5-efd8742b349e</link>
	     	<description><![CDATA[&amp;lt;sec&amp;lt; &amp;lt;b&amp;lt;Objective&amp;lt;/b&amp;lt; Autophagy is a highly conserved intracellular degradation pathway. Many picornaviruses induce autophagy to benefit viral replication, but an understanding of how autophagy occurs remains incomplete. In this study, we explored whether coxsackievirus B3 (CVB3) infection induced autophagy through endoplasmic reticulum (ER) stress.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt; &amp;lt;b&amp;lt;Methods&amp;lt;/b&amp;lt; In CVB3-infected HeLa cells, the specific molecules of ER stress and autophagy were detected using Western blotting, reverse transcription polymerase chain reaction (RT-PCR), and confocal microscopy. Then PKR-like ER protein kinase (PERK) inhibitor, inositol-requiring protein-1 (IRE1) inhibitor, or activating transcription factor-6 (ATF6) inhibitor worked on CVB3-infected cells, their effect on autophagy was assessed by Western blotting for detecting microtubule-associated protein light chain 3 (LC3).&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt; &amp;lt;b&amp;lt;Results&amp;lt;/b&amp;lt; CVB3 infection induced ER stress, and ER stress sensors PERK/eIF2α, IRE1/XBP1, and ATF6 were activated. CVB3 infection increased the accumulation of green fluorescent protein (GFP)-LC3 punctuation and induced the conversion from LC3-Ⅰ to phosphatidylethanolamine-conjugated LC3-1 (LC3-Ⅱ). CVB3 infection still decreased the expression of mammalian target of rapamycin (mTOR) and p-mTOR. Inhibition of PERK, IRE1, or ATF6 significantly decreased the ratio of LC3-Ⅱ to LC3-Ⅰ in CVB3-infected HeLa cells.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt; &amp;lt;b&amp;lt;Conclusion&amp;lt;/b&amp;lt; CVB3 infection induced autophagy through ER stress in HeLa cells, and PERK, IRE1, and ATF6a pathways participated in the regulation of autophagy. Our data suggested that ER stress may inhibit mTOR signaling pathway to induce autophagy during CVB3 infection.&amp;lt;/sec&amp;lt;]]></description>
	      	<volume>31</volume>
	      	<issue>12</issue>
	      	<startPage>867</startPage>
	      	<endPage>875</endPage>
	      	<author>
				Xiao Nuan LUO, Hai Lan YAO, Juan SONG, Qin Qin SONG, Bing Tian SHI, Dong XIA, Jun HAN
	      	</author>
	    </item>
    	    <item>
	       	<title>Sodium 4-phenylbutyrate Attenuates High-fat Diet-induced Impaired Spermatogenesis</title>
	      	<link>//article/id/1f990951-9bc2-4542-a68c-312061a32c47</link>
	     	<description><![CDATA[&amp;lt;sec&amp;lt; &amp;lt;b&amp;lt;Objective&amp;lt;/b&amp;lt; To determine the mitigating effects of sodium 4-phenylbutyrate (4-PBA) on high-fat diet (HFD)-induced spermatogenesis dysfunction.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt; &amp;lt;b&amp;lt;Methods&amp;lt;/b&amp;lt; Male rats (&amp;lt;i&amp;lt;n&amp;lt;/i&amp;lt;=30) were randomly divided into three groups:control, HFD, and 4-PBA (HFD +4-PBA). After 13 weeks, rats were euthanized. Testes and epididymis were harvested for further analysis. Sex hormones were detected, and hematoxylin and eosin staining was performed to examine the histological changes in the testes. Semen samples were collected to evaluate sperm quality. Spermatogenic cell apoptosis was detected by TUNEL assay.&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt; &amp;lt;b&amp;lt;Results&amp;lt;/b&amp;lt; Compared with the control group, the final body weight and body weight gain were significantly higher in HFD-fed rats, while the testicle/body weight ratios were lower (&amp;lt;i&amp;lt;P&amp;lt;/i&amp;lt; &amp;lt; 0.05). In HFD-fed rats, obvious pathological changes in the testicular tissue were observed. Treatment with 4-PBA attenuated HFD-induced histological damage, ameliorated the HFD-induced decrease in serum testosterone (T), and reduced the rate of testicular cell apoptosis (&amp;lt;i&amp;lt;P&amp;lt;/i&amp;lt; &amp;lt; 0.05) in obese male rats. Finally, 4-PBA significantly improved semen parameters in HFD rats (&amp;lt;i&amp;lt;P&amp;lt;/i&amp;lt; &amp;lt; 0.05).&amp;lt;/sec&amp;lt;&amp;lt;sec&amp;lt; &amp;lt;b&amp;lt;Conclusion&amp;lt;/b&amp;lt; HFD exposure induced detrimental effects on spermatogenesis, semen quality, serum T level, and testicular cell apoptosis in rats. Treatment with 4-PBA ameliorated HFD induced impaired spermatogenesis via inhibition of apoptosis in rats. 4-PBA may have therapeutic value in the treatment of obesity related impairment of spermatogenesis.&amp;lt;/sec&amp;lt;]]></description>
	      	<volume>31</volume>
	      	<issue>12</issue>
	      	<startPage>876</startPage>
	      	<endPage>882</endPage>
	      	<author>
				Er Hui WANG, San Qiao YAO, Ling TAO, Jin Yan XI
	      	</author>
	    </item>
    	    <item>
	       	<title>Incidence of Interpersonal Violence among Individuals with Drug Addiction Receiving Compulsory Treatment: A Survey at Two Drug Detention Centers in Hunan, China</title>
	      	<link>//article/id/a272abd3-af21-4bcf-afba-e81eddfcb2d6</link>
	     	<description><![CDATA[]]></description>
	      	<volume>31</volume>
	      	<issue>12</issue>
	      	<startPage>883</startPage>
	      	<endPage>887</endPage>
	      	<author>
				Xiao Lin WU, Yi Yun XIE, Pei Shan NING, Xiao Kang DI, David C. SCHWEBEL, Guo Qing HU
	      	</author>
	    </item>
    	    <item>
	       	<title>Effects of PM&amp;lt;sub&amp;lt;2.5&amp;lt;/sub&amp;lt; Exposure in Different Air Quality Grades on Daily Outpatient Visits for Childhood Asthma in Shijiazhuang, China</title>
	      	<link>//article/id/57b131f2-c840-4dc1-9ca7-798d13f3aeaf</link>
	     	<description><![CDATA[]]></description>
	      	<volume>31</volume>
	      	<issue>12</issue>
	      	<startPage>888</startPage>
	      	<endPage>892</endPage>
	      	<author>
				Gui Qin FU, Yan Feng JIANG, Lan Ping LIU, Hua Yue LIU, Ji ZHOU, Xiao Wei CUI, Shi Gong WANG
	      	</author>
	    </item>
    	    <item>
	       	<title>Effects on the Behavior and Neuroimmunity of Pulsed Microwaves with Different Peak Densities</title>
	      	<link>//article/id/18126051-d26f-46a6-b5e1-52ea41fccdd2</link>
	     	<description><![CDATA[]]></description>
	      	<volume>31</volume>
	      	<issue>12</issue>
	      	<startPage>893</startPage>
	      	<endPage>897</endPage>
	      	<author>
				Zhen Zhong YANG, Da Wei WU, Hong Bo MA, Jin Xue FEI, Ya Li ZHAO
	      	</author>
	    </item>
    	    <item>
	       	<title>Short-term Chronic Intermittent Hypobaric Hypoxia Alters Gut Microbiota Composition in Rats</title>
	      	<link>//article/id/ee50347a-e37c-4ed5-9c09-cf4dec1d2d97</link>
	     	<description><![CDATA[]]></description>
	      	<volume>31</volume>
	      	<issue>12</issue>
	      	<startPage>898</startPage>
	      	<endPage>901</endPage>
	      	<author>
				Yan Ming TIAN, Yue GUAN, Si Yu TIAN, Fang YUAN, Li ZHANG, Yi ZHANG
	      	</author>
	    </item>
    	    <item>
	       	<title>Dietary Behaviors and Influencing Factors among Rural Left-behind Children Aged below 7 Years in China</title>
	      	<link>//article/id/17904617-bc33-4cfe-af09-664c4c4c3824</link>
	     	<description><![CDATA[]]></description>
	      	<volume>31</volume>
	      	<issue>12</issue>
	      	<startPage>902</startPage>
	      	<endPage>907</endPage>
	      	<author>
				Chun Li FAN, Quan Fu MA, Jia You LUO, Xu Feng WU, Mi Yang LUO, Rong ZENG, Xiao Hui LI, Ya Mei LI, Jun Qun FANG
	      	</author>
	    </item>
    	    <item>
	       	<title>The Effects of Secondary Pneumonia on the Curative Efficacy of Multidrug-resistant Tuberculosis: A Retrospective Cohort Study</title>
	      	<link>//article/id/904d2dfc-0c18-43ae-84c4-d15ed7d7aa03</link>
	     	<description><![CDATA[]]></description>
	      	<volume>31</volume>
	      	<issue>12</issue>
	      	<startPage>908</startPage>
	      	<endPage>912</endPage>
	      	<author>
				Shou Yong TAN, Zhuo Zhi LIANG, Chiwala Gift, Hao Bin KUANG, Zhi Pei HUANG, Hong Juan QIN, Yan LI, Yan Qiong LI, H.M. Adnan Hameed, Tian Yu ZHANG
	      	</author>
	    </item>
    	    <item>
	       	<title>Study of the External Dose Rate and Retained Body Activity of Patients with Hyperthyroidism Who Are Receiving Ⅰ-131 Therapy</title>
	      	<link>//article/id/66c20773-69e6-4e6b-8966-b76e383d521d</link>
	     	<description><![CDATA[]]></description>
	      	<volume>31</volume>
	      	<issue>12</issue>
	      	<startPage>913</startPage>
	      	<endPage>916</endPage>
	      	<author>
				Yu Lian LIU, Zhi Xin ZHAO, Meng Hui HUO, Chen YIN, Jian TAN, Wen Yi ZHANG, Ling JIAO
	      	</author>
	    </item>
    	    <item>
	       	<title>Impact of Enterprise Ownership and Size on Registered Hematotoxicity in Benzene-exposed Workers</title>
	      	<link>//article/id/b2368123-acd4-4146-bdfe-feaf0ad8e0ec</link>
	     	<description><![CDATA[]]></description>
	      	<volume>31</volume>
	      	<issue>12</issue>
	      	<startPage>917</startPage>
	      	<endPage>921</endPage>
	      	<author>
				Bo Shen WANG, Lei HAN, Dan Dan YANG, Juan ZHANG, Li Hong YIN, Meng Ying ZHANG, Kai XU, Cai Hong XING, Bao Li ZHU, Yue Pu PU
	      	</author>
	    </item>
    	    <item>
	       	<title>&amp;lt;i&amp;lt;In Vitro&amp;lt;/i&amp;lt; Evaluation of Hemoperfusion for Chlorpyrifos Poisoning</title>
	      	<link>//article/id/f27861a9-6dbd-49a3-9bee-23316e08f8cc</link>
	     	<description><![CDATA[]]></description>
	      	<volume>31</volume>
	      	<issue>12</issue>
	      	<startPage>922</startPage>
	      	<endPage>926</endPage>
	      	<author>
				Xiang GUO, Cai Gao ZHONG, Yan Fang ZHANG, Fen LIU, Jian HE, Hui LIN, Mei Qiong GUO
	      	</author>
	    </item>
    	    <item>
	       	<title>The Mechanism and Influence of AKAP12 in Different Cancers</title>
	      	<link>//article/id/45e779fa-48ab-4446-bb56-424c190b4666</link>
	     	<description><![CDATA[]]></description>
	      	<volume>31</volume>
	      	<issue>12</issue>
	      	<startPage>927</startPage>
	      	<endPage>932</endPage>
	      	<author>
				Xuan WU, Tong WU, Ke LI, Yuan LI, Ting Ting HU, Wei Feng WANG, Su Jing QIANG, Shao Bo XUE, Wei Wei LIU
	      	</author>
	    </item>
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